A new measure for the analysis of epidemiological associations: Cannabis use disorder examples

by   Olga A. Vsevolozhskaya, et al.

Analyses of population-based surveys are instrumental to research on prevention and treatment of mental and substance use disorders. Population-based data provides descriptive characteristics of multiple determinants of public health and are typically available to researchers as an annual data release. To provide trends in national estimates or to update the existing ones, a meta-analytical approach to year-by-year data is typically employed with ORs as effect sizes. However, if the estimated ORs exhibit different patterns over time, some normalization of ORs may be warranted. We propose a new normalized measure of effect size and derive an asymptotic distribution for the respective test statistic. The normalization constant is based on the maximum range of the standardized log(OR), for which we establish a connection to the Laplace Limit Constant. Furthermore, we propose to employ standardized log(OR) in a novel way to obtain accurate posterior inference. Through simulation studies, we show that our new statistic is more powerful than the traditional one for testing the hypothesis OR=1. We then applied it to the United States population estimates of co-occurrence of side effect problem-experiences (SEPE) among newly incident cannabis users, based on the the National Survey on Drug Use and Health (NSDUH), 2004-2014.


page 1

page 2

page 3

page 4


Put the odds on your side: a new measure for epidemiological associations

The odds ratio (OR) is a measure of effect size commonly used in observa...

Maximum value of the standardized log of odds ratio and celestial mechanics

The odds ratio (OR) is a widely used measure of the effect size in obser...

Simulations for the Q statistic with constant and inverse variance weights for binary effect measures

Cochran's Q statistic is routinely used for testing heterogeneity in met...

Robust language-based mental health assessments in time and space through social media

Compared to physical health, population mental health measurement in the...

Computational Support for Substance Use Disorder Prevention, Detection, Treatment, and Recovery

Substance Use Disorders (SUDs) involve the misuse of any or several of a...

A modified maximum contrast method for unequal sample sizes in pharmacogenomic studies

In pharmacogenomic studies, biomedical researchers commonly analyze the ...

Please sign up or login with your details

Forgot password? Click here to reset