Enhancing Automated and Early Detection of Alzheimer's Disease Using Out-Of-Distribution Detection

by   Audrey Paleczny, et al.

More than 10.7 disease. Early diagnosis and treatment are crucial as most Alzheimer's patients are unaware of having it until the effects become detrimental. AI has been known to use magnetic resonance imaging (MRI) to diagnose Alzheimer's. However, models which produce low rates of false diagnoses are critical to prevent unnecessary treatments. Thus, we trained supervised Random Forest models with segmented brain volumes and Convolutional Neural Network (CNN) outputs to classify different Alzheimer's stages. We then applied out-of-distribution (OOD) detection to the CNN model, enabling it to report OOD if misclassification is likely, thereby reducing false diagnoses. With an accuracy of 98 outperformed our segmented volume model, which had detection and classification accuracies of 93 model enabled it to flag brain tumor images as OOD with 96 minimal overall accuracy reduction. By using OOD detection to enhance the reliability of MRI classification using CNNs, we lowered the rate of false positives and eliminated a significant disadvantage of using Machine Learning models for healthcare tasks. Source code available upon request.


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