Quantifying and Visualizing Vascular Branching Geometry with Micro-CT: Normalization of Intra- and Inter-Specimen Variations

by   Timothy L. Kline, et al.
Mayo Foundation for Medical Education and Research

Micro-CT images of the renal arteries of intact rat kidneys, which had their vasculature injected with the contrast agent polymer Microfil, were characterized. Measurement of inter-branch segment properties and the hierarchical structure of the vessel trees were computed by an automated algorithmic approach. The perfusion territories of the different kidneys, as well as the local diameters of the segmented vasculature were mapped onto the representative structures and visually explored. Various parameters were compared in order to outline key geometrical properties, properties which were shown to not have a wide range of inter-specimen variation. It is shown that the fractal scaling in non-symmetric branching reveals itself differently, than in symmetric branching (e.g., in the lung the mean bronchial diameters at each generation are closely related). Also, perfused tissue is shown to have very little inter-specimen variation and therefore could be used in future studies related to characterizing various disease states of tissues and organs based on vascular branching geometry.


page 2

page 4


A New 3D Segmentation Methodology for Lumbar Vertebral Bodies for the Measurement of BMD and Geometry

In this paper a new technique is presented that extracts the geometry of...

BRONCO: Automated modelling of the bronchovascular bundle using the Computed Tomography Images

Segmentation of the bronchovascular bundle within the lung parenchyma is...

CT Image Segmentation for Inflamed and Fibrotic Lungs Using a Multi-Resolution Convolutional Neural Network

The purpose of this study was to develop a fully-automated segmentation ...

Deep learning to estimate the physical proportion of infected region of lung for COVID-19 pneumonia with CT image set

Utilizing computed tomography (CT) images to quickly estimate the severi...

Geometric tree kernels: Classification of COPD from airway tree geometry

Methodological contributions: This paper introduces a family of kernels ...

Plane-Activated Mapped Microstructure

Querying and interacting with models of massive material micro-structure...

Please sign up or login with your details

Forgot password? Click here to reset