Assimilated LVEF: A Bayesian technique combining human intuition with machine measurement for sharper estimates of left ventricular ejection fraction and stronger association w

05/07/2018

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by   Thomas McAndrew, et al.

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The cardiologist's main tool for measuring systolic heart failure is left ventricular ejection fraction (LVEF). Trained cardiologist's report both a visual and machine-guided measurement of LVEF, but only use this machine-guided measurement in analysis. We use a Bayesian technique to combine visual and machine-guided estimates from the PARTNER-IIA Trial, a cohort of patients with aortic stenosis at moderate risk treated with bioprosthetic aortic valves, and find our combined estimate reduces measurement errors and improves the association between LVEF and a 1-year composite endpoint.