Challenges in systematic reviews and meta-analyses of mediation analyses

03/22/2021

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by   Tat-Thang Vo, et al.

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Systematic reviews and meta-analyses of mediation studies are increasingly being implemented in practice. Nonetheless, the methodology for conducting such review and analysis is still in a development phase, with much room for improvement. In this paper, we highlight and discuss challenges that investigators face in mediation systematic reviews and meta-analyses, then propose ways of accommodating these in practice.