HEROHE Challenge: assessing HER2 status in breast cancer without immunohistochemistry or in situ hybridization

11/08/2021
by   Eduardo Conde-Sousa, et al.
10

Breast cancer is the most common malignancy in women, being responsible for more than half a million deaths every year. As such, early and accurate diagnosis is of paramount importance. Human expertise is required to diagnose and correctly classify breast cancer and define appropriate therapy, which depends on the evaluation of the expression of different biomarkers such as the transmembrane protein receptor HER2. This evaluation requires several steps, including special techniques such as immunohistochemistry or in situ hybridization to assess HER2 status. With the goal of reducing the number of steps and human bias in diagnosis, the HEROHE Challenge was organized, as a parallel event of the 16th European Congress on Digital Pathology, aiming to automate the assessment of the HER2 status based only on hematoxylin and eosin stained tissue sample of invasive breast cancer. Methods to assess HER2 status were presented by 21 teams worldwide and the results achieved by some of the proposed methods open potential perspectives to advance the state-of-the-art.

READ FULL TEXT

page 8

page 9

page 10

page 11

research
06/17/2012

An Analysis of the Methods Employed for Breast Cancer Diagnosis

Breast cancer research over the last decade has been tremendous. The gro...
research
10/10/2015

Evaluation of Joint Multi-Instance Multi-Label Learning For Breast Cancer Diagnosis

Multi-instance multi-label (MIML) learning is a challenging problem in m...
research
11/09/2022

Gold-standard of HER2 breast cancer biopsies using supervised learning based on multiple pathologist annotations

Breast cancer is one of the most common cancer in women around the world...
research
03/15/2021

Exploring Genetic-histologic Relationships in Breast Cancer

The advent of digital pathology presents opportunities for computer visi...
research
06/21/2016

Crowdsourcing scoring of immunohistochemistry images: Evaluating Performance of the Crowd and an Automated Computational Method

The assessment of protein expression in immunohistochemistry (IHC) image...
research
02/20/2020

Bimodal Distribution Removal and Genetic Algorithm in Neural Network for Breast Cancer Diagnosis

Diagnosis of breast cancer has been well studied in the past. Multiple l...

Please sign up or login with your details

Forgot password? Click here to reset