On the fractional transversely isotropic functionally graded nature of soft biological tissues

by   Sachin Gunda, et al.

This paper focuses on the origin of the poroelastic anisotropic behaviour of the meniscal tissue and its spatially varying properties. We present confined compression creep test results on samples extracted from three parts of the tissue (Central body, Anterior horn and Posterior horn) in three orientations (Circumferential, Radial and Vertical). We show that a poroelastic model in which the fluid flow evolution is ruled by non-integer order operators (fractional Darcy's law) provides accurate agreement with the experimental creep data. The model is validated against two additional sets of experimental data: stress relaxation and fluid loss during the consolidation process measured as weight reduction. Results show that the meniscus can be considered as a transversely isotropic poroelastic material. This behaviour is due to the fluid flow rate being about three times higher in the circumferential direction than in the radial and vertical directions in the body region of the meniscus. In the anterior horn, the elastic properties are transversely isotropic, with the aggregate modulus higher in the radial direction than in the circumferential and vertical directions. The 3D fractional poroelastic model is implemented in finite element software and quantities such as flux of interstitial fluid during the consolidation process, a non-trivial experimental measure, are determined.


page 2

page 14


Study of human phonation in a full body domain

The Generation and propagation of the human voice is studied in two-dime...

Falling balls in a viscous fluid with contact: Comparing numerical simulations with experimental data

We evaluate a number of different finite element approaches for fluid-st...

A Data-Driven Memory-Dependent Modeling Framework for Anomalous Rheology: Application to Urinary Bladder Tissue

We introduce a data-driven fractional modeling framework aimed at comple...

The repulsion property in nonlinear elasticity and a numerical scheme to circumvent it

For problems in the calculus of cariations that exhibit the Lavrentiev p...

A New Method for Atlanta World Frame Estimation

In this paper, we propose a new Atlanta frame estimation method by consi...

Please sign up or login with your details

Forgot password? Click here to reset