Statistical matching of non-Gaussian data
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The statistical matching problem is a data integration problem with structured missing data. The general form involves the analysis of multiple datasets that only have a strict subset of variables jointly observed across all datasets. The simplest version involves two datasets, labelled A and B, with three variables of interest X, Y and Z. Variables X and Y are observed in dataset A and variables X and Z are observed in dataset B. Statistical inference is complicated by the absence of joint (Y, Z) observations. Parametric modelling can be challenging due to identifiability issues and the difficulty of parameter estimation. We develop computationally feasible procedures for the statistical matching of non-Gaussian data using suitable data augmentation schemes and identifiability constraints. Nearest-neighbour imputation is a common alternative technique due to its ease of use and generality. Nearest-neighbour matching is based on a conditional independence assumption that may be inappropriate for non-Gaussian data. The violation of the conditional independence assumption can lead to improper imputations. We compare model based approaches to nearest-neighbour imputation on a number of flow cytometry datasets and find that the model based approach can address some of the weaknesses of the nonparametric nearest-neighbour technique.
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