Learning Cost-Effective Treatment Regimes using Markov Decision Processes

10/21/2016
by   Himabindu Lakkaraju, et al.
0

Decision makers, such as doctors and judges, make crucial decisions such as recommending treatments to patients, and granting bails to defendants on a daily basis. Such decisions typically involve weighting the potential benefits of taking an action against the costs involved. In this work, we aim to automate this task of learning cost-effective, interpretable and actionable treatment regimes. We formulate this as a problem of learning a decision list -- a sequence of if-then-else rules -- which maps characteristics of subjects (eg., diagnostic test results of patients) to treatments. We propose a novel objective to construct a decision list which maximizes outcomes for the population, and minimizes overall costs. We model the problem of learning such a list as a Markov Decision Process (MDP) and employ a variant of the Upper Confidence Bound for Trees (UCT) strategy which leverages customized checks for pruning the search space effectively. Experimental results on real world observational data capturing judicial bail decisions and treatment recommendations for asthma patients demonstrate the effectiveness of our approach.

READ FULL TEXT

page 1

page 2

page 3

page 4

research
07/07/2021

Identifying optimally cost-effective dynamic treatment regimes with a Q-learning approach

Health policy decisions regarding patient treatment strategies require c...
research
12/01/2016

Transfer Learning Across Patient Variations with Hidden Parameter Markov Decision Processes

Due to physiological variation, patients diagnosed with the same conditi...
research
09/09/2011

Integrating Learning from Examples into the Search for Diagnostic Policies

This paper studies the problem of learning diagnostic policies from trai...
research
11/27/2020

Finding Optimal Cancer Treatment using Markov Decision Process to Improve Overall Health and Quality of Life

Markov Decision Processes and Dynamic Treatment Regimes have grown incre...
research
10/05/2018

Sequential Patient Recruitment and Allocation for Adaptive Clinical Trials

Randomized Controlled Trials (RCTs) are the gold standard for comparing ...
research
07/11/2020

Distangling Biological Noise in Cellular Images with a focus on Explainability

The cost of some drugs and medical treatments has risen in recent years ...
research
10/17/2010

Identifying the consequences of dynamic treatment strategies: A decision-theoretic overview

We consider the problem of learning about and comparing the consequences...

Please sign up or login with your details

Forgot password? Click here to reset